Prequel Skin Hypochlorous Acid Spray
Brand: Prequel Skin Category: Personal Care
Hypochlorous acid (HOCl) is having a skincare moment—and for good reason. It's the same molecule your white blood cells produce to fight infection. In spray form, it's antimicrobial, anti-inflammatory, and incredibly gentle. Originally used in wound care, it's now a cult favorite for acne, rosacea, and irritated skin.
Prequel's version is a simple, stabilized HOCl spray that can be used all over face and body.
Safety Analysis
HOCl is one of the safest antimicrobials available—it's literally what your body makes. It kills bacteria, viruses, and fungi without irritation. Safe for all skin types including sensitive, baby skin, and around eyes.
Concerns addressed: No sting, no irritation. Safe for eczema, rosacea, acne. Safe around eyes. Safe for children. Non-toxic if ingested.
Efficacy Analysis
Research supports HOCl for:
- Killing acne-causing bacteria
- Reducing inflammation
- Accelerating wound healing
- Calming rosacea flares
- Post-procedure skin healing
It's not a miracle cure, but as a daily antimicrobial that doesn't cause resistance or irritation, it's valuable. Use after cleansing or throughout the day as a calming mist.
Value Analysis
At $25-30 for a bottle lasting 1-2 months, it's moderately priced. DIY HOCl devices exist but require maintenance. Tower 28 SOS Spray is similar at comparable pricing.
Cost per month: ~$15-20 Comparable alternatives: Tower 28 SOS Spray ($28), DIY HOCl generators ($100+ upfront), prescription antibiotics (requires Rx)
The Bottom Line
Prequel Hypochlorous Acid Spray is a genuinely useful, research-backed product for anyone dealing with acne, irritation, or inflammation. It's as gentle as water but antimicrobial—a rare combination. Worth keeping in your medicine cabinet.
Best for: Acne-prone skin, post-procedure healing, rosacea, eczema, maskne, cuts/scrapes, general skin calming.
Skip if: You're looking for dramatic transformations, prefer all-in-one products, or are very budget-conscious.





